Split enchantment and Twinned spell, can they be applied to the same spell?

@JeremyECrawford split enchantment and twinned spell, can they be applied to the same spell?

— Eric Green (@quadhund) November 24, 2016

Split Enchantment and Twinned Spell are mutually exclusive. When you use one of them, the spell no longer targets only one creature. #DnD https://t.co/R6Wz36krsF

— Jeremy Crawford (@JeremyECrawford) November 24, 2016