Can you cast enlarge and then allow the double’d damage die of large weapons?

@mikemearls @ChrisPerkinsDnD can you cast enlarge/reduce on someone, and then allow them to use the double'd damage die of large weapons?

— Morris Kennedy (@elsuperperson) January 17, 2017

Not what the spell does, but it's your game! #WOTCstaff https://t.co/32f3Gi0M0J

— Christopher Perkins (@ChrisPerkinsDnD) January 17, 2017